ATR: an essential regulator of genome integrity
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm2450.pdf
Reference189 articles.
1. Cortez, D., Guntuku, S., Qin, J. & Elledge, S. J. ATR and ATRIP: partners in checkpoint signaling. Science 294, 1713–1716 (2001). Reported the identification of ATRIP and, along with reference 129, demonstrated that ATR is essential for cell viability.
2. Brown, E. J. & Baltimore, D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14, 397–402 (2000).
3. de Klein, A. et al. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr. Biol. 10, 479–482 (2000). Reported, together with reference 2, that disruption of ATR in mice causes early embryonic lethality.
4. Nyberg, K. A., Michelson, R. J., Putnam, C. W. & Weinert, T. A. Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36, 617–656 (2002).
5. Shechter, D., Costanzo, V. & Gautier, J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair (Amst.) 3, 901–908 (2004).
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