Functional screening and rational design of compounds targeting GPR132 to treat diabetes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
https://www.nature.com/articles/s42255-023-00899-4.pdf
Reference69 articles.
1. Taylor, R., Al-Mrabeh, A. & Sattar, N. Understanding the mechanisms of reversal of type 2 diabetes. Lancet Diabetes Endocrinol. 7, 726–736 (2019).
2. Siehler, J., Blochinger, A. K., Meier, M. & Lickert, H. Engineering islets from stem cells for advanced therapies of diabetes. Nat. Rev. Drug Discov. 20, 920–940 (2021).
3. Talchai, C., Xuan, S., Lin, H. V., Sussel, L. & Accili, D. Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 150, 1223–1234 (2012).
4. Ying, W. et al. Expansion of islet-resident macrophages leads to inflammation affecting beta cell proliferation and function in obesity. Cell Metab. 29, 457–474 (2019).
5. Ying, W., Fu, W., Lee, Y. S. & Olefsky, J. M. The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. Nat. Rev. Endocrinol. 16, 81–90 (2020).
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