Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

Author:

Bachmaier Kurt,Krawczyk Connie,Kozieradzki Ivona,Kong Young-Yun,Sasaki Takehiko,Oliveira-dos-Santos Antonio,Mariathasan Sanjeev,Bouchard Dennis,Wakeham Andrew,Itie Annick,Le Jenny,Ohashi Pamela S.,Sarosi Ildiko,Nishina Hiroshi,Lipkowitz Stan,Penninger Josef M.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference23 articles.

1. Healy, J. I. & Goodnow, C. C. Positive versus negative signalling by lymphocyte antigen receptors. Annu. Rev. Immunol. 16, 645–670 (1998).

2. Rudd, C. E. Adaptors and molecular scaffolds in immune cell signalling. Cell 96, 5–8 (1999 ).

3. Cory, G. O. C. et al. The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J. Exp. Med. 182, 611– 615 (1995).

4. Sawasdikosol, S. et al. Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. J. Immunol. 157, 110–116 (1996).

5. Keane, M. M., RiveroLezcano, O. M., Mitchell, J. A., Robbins, K. C. & Lipkowitz, S. Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene 10, 2367–2377 ( 1995).

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