Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors-Reference-Cited by-同舟云学术

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Published:2016-03-07 Issue:4 Volume:23 Page:293-299
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Yin Jie,Babaoglu Kerim,Brautigam Chad A,Clark Lindsay,Shao Zhenhua,Scheuermann Thomas H,Harrell Charles M,Gotter Anthony L,Roecker Anthony J,Winrow Christopher J,Renger John J,Coleman Paul J,Rosenbaum Daniel M

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb.3183.pdf

Reference65 articles.

1. Marcus, J.N. et al. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435, 6–25 (2001).

2. Li, J., Hu, Z. & de Lecea, L. The hypocretins/orexins: integrators of multiple physiological functions. Br. J. Pharmacol. 171, 332–350 (2014).

3. Sakurai, T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573–585 (1998).

4. de Lecea, L. et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA 95, 322–327 (1998).

5. Lin, L. et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365–376 (1999).

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