Integrating cell-signalling pathways with NF-κB and IKK function
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm2083.pdf
Reference136 articles.
1. Hayden, M. S. & Ghosh, S. Signaling to NF-κB. Genes Dev. 18, 2195–2224 (2004). This review of the mechanisms of NF-κB activation provides a comprehensive analysis of the NF-κB-signalling pathway.
2. Bonizzi, G. & Karin, M. The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25, 280–288 (2004).
3. Gerondakis, S., Grossmann, M., Nakamura, Y., Pohl, T. & Grumont, R. Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts. Oncogene 18, 6888–6895 (1999).
4. Pasparakis, M., Luedde, T. & Schmidt-Supprian, M. Dissection of the NF-κB signalling cascade in transgenic and knockout mice. Cell Death Differ. 13, 861–872 (2006). Genetic experiments in mice provide much of the basis for our understanding of the NF-κB and IKK pathway. Reference 3 summarizes fundamental information about different NF-κB-, IκB- and IKK-knockout mouse phenotypes. Reference 4 describes how these mice have been used to study the role of the NF-κB and IKK pathway in physiological processes and human diseases. These reviews are both essential reading.
5. Pahl, H. L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18, 6853–6866 (1999).
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