A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations-Reference-Cited by-同舟云学术

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

Published:2011-05-08 Issue:6 Volume:18 Page:721-727
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Toledo Luis I,Murga Matilde,Zur Rafal,Soria Rebeca,Rodriguez Antonio,Martinez Sonia,Oyarzabal Julen,Pastor Joaquin,Bischoff James R,Fernandez-Capetillo Oscar

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb.2076.pdf

Reference50 articles.

1. Lempiäinen, H. & Halazonetis, T.D. Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J. 28, 3067–3073 (2009).

2. López-Contreras, A.J. & Fernandez-Capetillo, O. The ATR barrier to replication-born DNA damage. DNA Repair (Amst.) 9, 1249–1255 (2010).

3. Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864–870 (2005).

4. Gorgoulis, V.G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907–913 (2005).

5. Halazonetis, T.D., Gorgoulis, V.G. & Bartek, J. An oncogene-induced DNA damage model for cancer development. Science 319, 1352–1355 (2008).

Cited by 412 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. SLFN11 and ATR as targets for overcoming cisplatin resistance in ovarian cancer cells;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2024-12

2. Targeting the ATM pathway in cancer: Opportunities, challenges and personalized therapeutic strategies;Cancer Treatment Reviews;2024-09

3. Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors;Cancer Gene Therapy;2024-08-09

4. Chemo-Phosphoproteomic Profiling with ATR Inhibitors Berzosertib and Gartisertib Uncovers New Biomarkers and DNA Damage Response Regulators;Molecular & Cellular Proteomics;2024-08

5. Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells;Advanced Science;2024-07-08