Abstract
Abstract: Foregut malformations are relatively common anomalies, occurring
in 1 in 2000–5000 live births. The adriamycin‐induced rat model of the VATER
association has provided a means of studying the morphogenesis of a variety of major
congenital structural abnormalities similar to those seen in humans with VATER association.
The secreted glycoprotein, Sonic hedgehog (Shh), may act as an endodermal signal
that controls gut and lung patterning. Mice with targeted deletion of Shh
have foregut defects that are consistent with those produced by administration of
adriamycin. It is possible that mutations induced by adriamycin may result from the
breakdown of the Shh signalling pathway.
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36 articles.
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