Genetic Epidemiology of Migraine and Cluster Headache

Abstract

Migraine. The present genetic epidemiological survey of migraine was based on semi-structured interviews by a physician. The operational diagnostic criteria of the International Headache Society were used. Three thousand males and 1,000 females aged 40 were drawn from the Danish National Central Person Registry. They received a questionnaire by post regarding migraine and the response rate was 87%. People with self-reported migraine and a random sample reporting no migraine were invited to a headache interview and physical and neurological examination. Those not reacting to the invitation were interviewed by telephone. The participation of the interview was 87%. Kappa was 0.77 validating self-reported migraine against a clinical interview by a physician. Non-responders did not differ from responders regarding migraine. The lifetime prevalence of MO and MA was 9.3% and 6.3% in males and 20.1% and 9.6% in females. People with MA were included as probands in the family study. An equivalent number of probands with MO and probands who had never had migraine were random samples of the people with MO) and those who had never had migraine, respectively. First-degree relatives and spouses were interviewed blindly by a physician. The 378 probands had 1,109 first-degree relatives and 229 spouses. Compared with the general population, the first-degree relatives of probands with MO had a 1.9-fold increased risk of MO and a 1.4-fold increased risk of MA, after standardization for sex and age. The first-degree relatives of probands with MA had a 3.8-fold increased risk of MA and no increased risk of MO. The first-degree relatives of probands who had never had migraine had no increased risk of either MO or MA. Spouses to pro-bands with MC) had a 1.5-fold increased risk of MO, while spouses to probands with MA had no increased risk of MA. The familial patterns indicate that MO and MA are distinct entities. The familial occurrence suggests that MO is caused by a combination of genetic and environmental factors, while MA is determined mainly or exclusively by genetic factors. The complex segregation analysis supports the importance of genetic factors and suggests multifactorial inheritance without generational difference in both MO and MA, but genetic heterogeneity cannot be excluded.