Clinicopathological study of multiple superficial oesophageal carcinoma

Author:

Kanamoto A1,Yamaguchi H1,Nakanishi Y2,Tachimori Y3,Kato H3,Watanabe H3

Affiliation:

1. Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan

2. Pathology Division, National Cancer Center Research Institute, Tokyo, Japan

3. Department of Surgery, National Cancer Center Hospital, Tokyo, Japan

Abstract

Abstract Background Recently, the diagnosis of superficial oesophageal carcinoma has increased markedly in Japan as a result of advances in endoscopy. A number of these carcinomas have proved to be multiple. Methods Some 359 patients with superficial squamous cell carcinoma of the oesophagus who underwent oesophagectomy (n = 276) or endoscopic mucosal resection (EMR) (n = 83) were reviewed retrospectively. The clinicopathological features of patients with multiple superficial oesophageal carcinoma were compared with those of patients with a single superficial oesophageal carcinoma. Results Of the 359 patients, 99 (28 per cent) had multiple superficial oesophageal carcinoma. The male: female ratio in patients with multiple carcinoma was 98: 1, compared with 5·3: 1 for those with a single carcinoma (n = 260) (P = 0·0001). The incidence of tobacco and alcohol use was significantly higher in the patients with multiple carcinoma than in those with a single carcinoma (P = 0·04 and P = 0·03 respectively). The incidence of pharyngeal malignancy was also significantly higher in patients with multiple carcinoma (P = 0·02). Conclusion The high incidence of multiple superficial oesophageal carcinoma indicates a need for careful evaluation of the oesophagus at the time of initial diagnosis, treatment and follow-up for superficial oesophageal carcinoma. Male sex, smoking, alcohol use and the presence of pharnygeal malignancy are high-risk factors for multiple superficial oesophageal carcinoma.

Publisher

Oxford University Press (OUP)

Subject

Surgery

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