Amide Hydrolysis of a Novel Chemical Series of Microsomal Prostaglandin E Synthase-1 Inhibitors Induces Kidney Toxicity in the Rat

Author:

Bylund Johan,Annas Anita,Hellgren Dennis,Bjurström Sivert,Andersson Håkan,Svanhagen Alexander

Publisher

Elsevier BV

Reference21 articles.

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3. Bylund J, Ek ME, Kers A, Nordvall G, Ohberg L, Viklund J, von Berg S, Holenz J, Narhi K, Sohn D, and Johansson MH (2009) inventors, AstraZeneca AB, assignee. Bis-(sulfonylamino) derivatives in therapy 065. U.S. patent 2009/0131468 A1. 2009 May 21.

4. Pharmacokinetics, COX-2 specificity, and tolerability of supratherapeutic doses of rofecoxib in humans;Depré;Eur J Clin Pharmacol,2000

5. Relation between renal and hepatic excretion of drugs. XI. Excretion of sulfonamides with various physico-chemical properties of different ages—influence of nephrectomy or bile duct ligation;Fleck;Exp Pathol,1988

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