A-770041, a Novel and Selective Small-Molecule Inhibitor of Lck, Prevents Heart Allograft Rejection-Reference-Cited by-同舟云学术

A-770041, a Novel and Selective Small-Molecule Inhibitor of Lck, Prevents Heart Allograft Rejection

Published:2005-07-12 Issue:1 Volume:315 Page:36-41
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Stachlewitz Robert F.,Hart Michelle A.,Bettencourt Brian,Kebede Tegest,Schwartz Annette,Ratnofsky Sheldon E.,Calderwood David J.,Waegell Wendy O.,Hirst Gavin C.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference25 articles.

1. The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

2. A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection

3. p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.

4. Use of a Heterotopic Cardiac Isotransplant for Pharmacological and Toxicological Studies*

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