Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader
Author:
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Subject
Pharmaceutical Science,Pharmacology
Reference33 articles.
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3. Food and Drug Administration (2017) In vitro metabolism- and transporter-mediated drug-drug interaction studies guidance for industry, Food and Drug Administration, Silver Spring, MD.
4. Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by x-ray crystallography and NMR
5. Hamilton EP Patel MR Armstrong AC Baird RD Jhaveri K Hoch M Klinowska T Lindemann JPO Morgan S Schiavon G . (2018) A first-in-human study of the new oral selective estrogen receptor degrader AZD9496 for ER+/HER2- advanced breast cancer. Clin Cancer Res DOI: 10.1158/1078-0432.CCR-17-3102 [published ahead of print].
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