Stereoselective Conjugation of Oxazepam by Human UDP-Glucuronosyltransferases (UGTs): S-Oxazepam Is Glucuronidated by UGT2B15, While R-Oxazepam Is Glucuronidated by UGT2B7 and UGT1A9

Author:

Court Michael H.,Duan Su X.,Guillemette Chantal,Journault Kim,Krishnaswamy Soundararajan,von Moltke Lisa L.,Greenblatt David J.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference25 articles.

1. Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam and acetaminophen.;Abernethy;J Lab Clin Med,1983

2. 3′-azido-3′-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).;Barbier;Drug Metab Dispos,2000

3. The glucuronidation of opioids, other xenobiotics and androgens by human UGT2B7Y(268) and UGT2B7H(268).;Coffman;Drug Metab Dispos,1998

4. Biochemical basis for deficient paracetamol glucuronidation in cats: an interspecies comparison of enzyme constraint in liver microsomes.;Court;J Pharm Pharmacol,1997

5. Molecular basis for deficient acetaminophen glucuronidation in cats

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