Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam-Reference-Cited by-同舟云学术

Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Published:2021-10-07 Issue:1 Volume:50 Page:65-75
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Fowler Stephen,Brink Andreas,Cleary Yumi,Günther Andreas,Heinig Katja,Husser Christophe,Kletzl Heidemarie,Kratochwil Nicole,Mueller Lutz,Savage Mark,Stillhart Cordula,Tuerck Dietrich,Ullah Mohammed,Umehara Kenichi,Poirier Agnès

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

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5. Model-based investigation of CYP3A enzyme inactivation effect of risdiplam in infants, children and adults with spinal muscular atrophy (SMA);Cleary;Clin Pharmacol Ther,2021

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