Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles-Reference-Cited by-同舟云学术

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Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles

Published:2020-03-19 Issue:6 Volume:48 Page:508-514
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Barr John T.,Wang Zhican,Min Xiaoshan,Wienkers Henry J.,Rock Brooke M.,Rock Dan A.,Wienkers Larry C.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference34 articles.

1. Time-Dependent Inactivation of P450 3A4 by Raloxifene: Identification of Cys239 as the Site of Apoprotein Alkylation1

2. Mechanism-based inhibition of CYP3A4 by podophyllotoxin: aging of an intermediate is important for in vitro/in vivo correlations;Barnaba;Mol Pharm,2016

3. Detection of Covalent Adducts to Cytochrome P450 3A4 Using Liquid Chromatography Mass Spectrometry

4. Pyrene·Pyrene Complexes at the Active Site of Cytochrome P450 3A4: Evidence for a Multiple Substrate Binding Site

5. 1-Aminobenzotriazole: a mechanism-based cytochrome P450 inhibitor and probe of cytochrome P450 biology;de Montellano;Med Chem (Los Angeles),2018

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1. The Importance of Tracking “Missing” Metabolites: How and Why?;Journal of Medicinal Chemistry;2023-09-28

2. Unraveling a Combined Inactivation Mechanism of Cytochrome P450s by Genipin, the Major Reactive Aglycone Derived from Gardeniae Fructus;Chemical Research in Toxicology;2023-08-25

3. Characterization of Cytochrome P450 Mechanism Based Inhibition;Drug Metabolism Handbook;2022-11-18

4. Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5;Molecular Pharmacology;2021-07-01

5. Kinetics of cytochrome P450 3A4 inhibition by heterocyclic drugs defines a general sequential multistep binding process;Journal of Biological Chemistry;2021-01

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