Association between Atopic Dermatitis and Hyperuricemia in the Adult Korean Population based on the 7th and 8th Korea National Health and Nutrition Examination Survey

Abstract

Background: Serum uric acid levels have been reported to be associated with various conditions including psoriasis and metabolic syndrome, but their relationship with atopic dermatitis has not been studied adequately. This study aimed to investigate the association of atopic dermatitis with serum uric acid level and hyperuricemia in adult females and males.Methods: Using data from the 7th and 8th Korea National Health and Nutrition Examination Survey, multiple linear and logistic regression analyses were performed to assess the association of atopic dermatitis with serum uric acid level and hyperuricemia respectively, with adjustment for potential confounding factors in females and males aged 19 years or older, respectively.Results: The study population included 14,504 female and 12,147 male participants. When adjusting for potential confounding factors, females with atopic dermatitis had a mean serum uric acid level of 0.13 mg/dL (95% confidence interval [CI], 0.03-0.24) higher than those without atopic dermatitis (<i>P</i>=0.013), and hyperuricemia was also more frequent in females with atopic dermatitis than those without atopic dermatitis (adjusted odds ratio, 1.86; 95% CI, 1.27-2.72; <i>P</i>=0.002). On the other hand, there were no significant differences in mean serum uric acid level and frequency of hyperuricemia between males with and without atopic dermatitis when adjusting for potential confounding factors.Conclusions: These results show a close relationship of atopic dermatitis with elevated serum uric acid level and hyperuricemia in Korean adult females but not males.