High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators
Author:
Affiliation:
1. Department of Chemistry, University of California, Davis, California 95616, United States
2. Departments of Medicine & Physiology, University of California, San Francisco, California 94143, United States
Funder
National Eye Institute
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Biomedical Imaging and Bioengineering
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01759
Reference25 articles.
1. Chloride channels as drug targets
2. Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase.
3. Drug-induced secretory diarrhea: A role for CFTR
4. Mechanisms of action of cholera and Escherichia coli enterotoxins
5. CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation
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