Discovery of the Potent and Selective M1 PAM-AgonistN-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects-Reference-Cited by-同舟云学术

Discovery of the Potent and Selective M1 PAM-AgonistN-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Published:2016-07-01 Issue:13 Volume:59 Page:6313-6328
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Davoren Jennifer E.,Lee Che-Wah,Garnsey Michelle,Brodney Michael A.,Cordes Jason,Dlugolenski Keith,Edgerton Jeremy R.,Harris Anthony R.,Helal Christopher J.,Jenkinson Stephen¹,Kauffman Gregory W.,Kenakin Terrence P.²,Lazzaro John T.,Lotarski Susan M.,Mao Yuxia,Nason Deane M.,Northcott Carrie,Nottebaum Lisa¹,O’Neil Steven V.,Pettersen Betty,Popiolek Michael,Reinhart Veronica,Salomon-Ferrer Romelia,Steyn Stefanus J.,Webb Damien,Zhang Lei,Grimwood Sarah

Affiliation:

1. Drug Safety Research and Development, Pfizer Worldwide Research and Development, La Jolla, California 92121, United States

2. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00544

Reference114 articles.

1. A Selective Allosteric Potentiator of the M₁Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning

2. Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System

3. Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

4. Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia

5. Muscarinic M1 agonists in the treatment of Alzheimer’s disease

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