Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development-Reference-Cited by-同舟云学术

Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Published:2017-03-24 Issue:7 Volume:60 Page:2819-2839
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Aguilar Angelo¹,Lu Jianfeng¹,Liu Liu¹,Du Ding¹^ORCID,Bernard Denzil¹,McEachern Donna¹,Przybranowski Sally¹,Li Xiaoqin²,Luo Ruijuan²,Wen Bo²,Sun Duxin²,Wang Hengbang³⁴,Wen Jianfeng³⁴,Wang Guangfeng³⁴,Zhai Yifan³⁴,Guo Ming³⁴,Yang Dajun³⁴⁵,Wang Shaomeng¹^ORCID

Affiliation:

1. University of Michigan Comprehensive Cancer Center, and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States

2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Jiangsu Ascentage Biomed Development Inc., China Medical City, Taizhou, Jiangsu 225300, China

4. Suzhou Ascentage Pharma Inc., Suzhou, Jiangsu 215123, China

5. Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, China

Funder

National Cancer Institute

Ministry of Science and Technology of the People's Republic of China

Guangdong Province

Ascentage Pharma Group Corporation, Ltd.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01665

Reference35 articles.