Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis

Author:

Lu Weiqiang12,Yao Xue1,Ouyang Ping1,Dong Ningning1,Wu Dang1,Jiang Xingwu2,Wu Zengrui1,Zhang Chen1,Xu Zhongyu1,Tang Yun1ORCID,Zou Shien3,Liu Mingyao2,Li Jian1ORCID,Zeng Minghua4,Lin Ping5,Cheng Feixiong567ORCID,Huang Jin1

Affiliation:

1. Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

2. Shanghai Key Laboratory of Regulatory Biology, The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China

3. Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China

4. Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education), School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China

5. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, Sichuan, China

6. Center for Complex Networks Research, Northeastern University, Boston, Massachusetts 02115, United States

7. Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, United States

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Shanghai Committee of Science and Technology

Guangxi Committee of Science and Technology

Guangxi Province

BAGUI scholar program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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