Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA–PABA–MAC and 5-ASA–PABA–Diamine for the Treatment of Ulcerative Colitis-Reference-Cited by-同舟云学术

Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA–PABA–MAC and 5-ASA–PABA–Diamine for the Treatment of Ulcerative Colitis

Published:2022-03-11 Issue:6 Volume:65 Page:4926-4948
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhao Jiaxing¹,Zhang Bing¹^ORCID,Mao Qing¹,Ping Kunqi¹,Zhang Peng¹,Lin Fengwei¹,Liu Dan²,Feng Yao¹,Sun Ming¹,Zhang Yan³,Li Qiu Hua¹,Zhang Tingjian⁴,Mou Yanhua³,Wang Shaojie¹^ORCID

Affiliation:

1. Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China

2. Shenyang Hinewy Pharmaceutical Technology Co., Ltd., 41 Liutang Road, Shenhe District, Shenyang 110016, China

3. Department of Pharmacology, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China

4. School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02166

Reference86 articles.

1. Ulcerative colitis

2. Ulcerative Colitis: Shifting Sands