Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors-Reference-Cited by-同舟云学术

Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors

Published:2021-09-07 Issue:18 Volume:64 Page:13551-13571
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Li¹,Tang Manshu²,Pragani Rajan¹,Whitby Frank G.³,Zhang Ya-qin¹,Balakrishnan Bijina²,Fang Yuhong¹,Karavadhi Surendra¹,Tao Dingyin¹^ORCID,LeClair Christopher A.¹^ORCID,Hall Matthew D.¹^ORCID,Marugan Juan J.¹^ORCID,Boxer Matthew¹,Shen Min¹,Hill Christopher P.³,Lai Kent²,Patnaik Samarjit¹^ORCID

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

2. Department of Pediatrics, University of Utah, Salt Lake City, Utah 84108-6500, United States

3. Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, Utah 84112, United States

Funder

National Center for Advancing Translational Sciences

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00945

Reference49 articles.

1. Congenital Galactosemia, a Single Enzymatic Block in Galactose Metabolism

2. Galactosemia, a congenital defect in a nucleotide transferase

3. The enzymatic transformation of uridine diphosphate glucose into a galactose derivative

4. Galactose-1-phosphate in the pathophysiology of galactosemia

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