Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction-Reference-Cited by-同舟云学术

Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction

Published:2021-10-29 Issue:21 Volume:64 Page:16213-16241
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Reutershan Michael H.¹^ORCID,Machacek Michelle R.¹,Altman Michael D.¹,Bogen Stephane²,Cai Mingmei¹,Cammarano Carolyn¹,Chen Dapeng¹,Christopher Matthew¹,Cryan John¹,Daublain Pierre¹,Fradera Xavier¹^ORCID,Geda Prasanthi¹,Goldenblatt Peter¹,Hill Armetta D.¹,Kemper Raymond A.¹,Kutilek Victoria¹,Li Chaomin¹^ORCID,Martinez Michelle¹,McCoy Mark²^ORCID,Nair Latha²,Pan Weidong²,Thompson Christopher F.¹,Scapin Giovanna²,Shizuka Manami¹,Spatz Marianne L.¹,Steinhuebel Dietrich¹,Sun Binyuan¹,Voss Matthew E.³,Wang Xiao⁴^ORCID,Yang Liping¹,Yeh Tammie C.¹,Dussault Isabelle¹,Marshall C. Gary¹,Trotter B. Wesley¹

Affiliation:

1. Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

2. Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, New Jersey 07032, United States

3. Albany Molecular Research Inc., 61 Science Park Road, Singapore (West) 117525, Singapore

4. Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

Funder

Merck Sharp and Dohme

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01524

Reference56 articles.

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4. The genetics of the p53 pathway, apoptosis and cancer therapy

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