Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A-Reference-Cited by-同舟云学术

Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A

Published:2022-01-31 Issue:5 Volume:65 Page:4018-4029
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tu Dongzhu¹,Ning Jing²,Zou Liwei¹,Wang Ping¹,Zhang Yani¹,Tian Xiangge²,Zhang Feng¹,Zheng Jiang³⁴^ORCID,Ge Guangbo¹^ORCID

Affiliation:

1. Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

2. Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Integrative Medicine, National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, College of Pharmacy, Dalian Medical University, Dalian 116044, China

3. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China

4. State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang 550025, China

Funder

Ministry of Science and Technology of the People's Republic of China

Shanghai Municipal Education Commission

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Shanghai Education Development Foundation

Shanghai Talent Development Fund

Project of National Multidisciplinary Innovation Team of Traditional Chinese Medicine

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine