Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach-Reference-Cited by-同舟云学术

Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach

Published:2021-11-03 Issue:21 Volume:64 Page:15810-15824
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Prakash Muthuraj¹,Itoh Yukihiro¹²^ORCID,Fujiwara Yoshie³,Takahashi Yukari¹,Takada Yuri²,Mellini Paolo¹,Elboray Elghareeb E.¹⁴,Terao Mitsuhiro²,Yamashita Yasunobu²,Yamamoto Chika⁵,Yamaguchi Takao⁵^ORCID,Kotoku Masayuki¹,Kitao Yuki¹,Singh Ritesh¹⁶,Roy Rohini³⁷,Obika Satoshi⁵^ORCID,Oba Makoto¹^ORCID,Wang Dan Ohtan³⁸⁹,Suzuki Takayoshi¹²¹⁰^ORCID

Affiliation:

1. Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan

2. SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan

3. Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan

4. Chemistry Department, Faculty of Science, South Valley University, Qena 83523, Egypt

5. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan

6. Department of Chemistry, Central University of Rajasthan, NH-8, Bandar Sindri, Ajmer 305817, Rajasthan, India

7. Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan

8. Center for Biosystems Dynamics Research, RIKEN, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

9. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China

10. CREST, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Core Research for Evolutional Science and Technology

Japan Agency for Medical Research and Development

Tokyo Biochemical Research Foundation

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01107

Reference51 articles.

1. Computations Reveal a Rich Mechanistic Variation of Demethylation of N-Methylated DNA/RNA Nucleotides by FTO

2. Conformational flexibility influences structure–function relationships in nucleic acid N-methyl demethylases

3. Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair

4. The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

5. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily

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