Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases

Author:

Cheng Peter T. W.1ORCID,Kaltenbach Robert F.1,Zhang Hao1,Shi Jun1,Tao Shiwei1,Li Jun1ORCID,Kennedy Lawrence J.1,Walker Steven J.1,Shi Yan1,Wang Ying1,Dhanusu Suresh2,Reddigunta Ramesh2,Kumaravel Selvakumar2,Jusuf Sutjano3,Smith Daniel4,Krishnananthan Subramaniam4,Li Jianqing5ORCID,Wang Tao6,Heiry Rebekah6,Sum Chi Shing6,Kalinowski Stephen S.7,Hung Chen-Pin7,Chu Ching-Hsuen7,Azzara Anthony V.7,Ziegler Milinda7,Burns Lisa7,Zinker Bradley A.7,Boehm Stephanie7,Taylor Joseph7,Sapuppo Julia7,Mosure Kathy8,Everlof Gerry9,Guarino Victor10,Zhang Lisa10,Yang Yanou11,Ruan Qian11ORCID,Xu Carrie12,Apedo Atsu13,Traeger Sarah C.14,Cvijic Mary Ellen6,Lentz Kimberley A.10,Tirucherai Giridhar15,Sivaraman Lakshmi16,Robl Jeffrey1,Ellsworth Bruce A.1ORCID,Rosen Glenn7,Gordon David A.7,Soars Matthew G.8,Gill Michael17,Murphy Brian J.7

Affiliation:

1. Fibrosis Chemistry, Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

2. Biocon-Bristol Myers Squibb Research & Development Center, Bangalore 560099, India

3. Computer Aided Drug Design, Molecular Structure & Design, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

4. Discovery Chemistry Synthesis, Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

5. Discovery Chemistry Synthesis, Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Cambridge, Massachusetts 02140, United States

6. Lead Evaluation, Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

7. Cardiovascular & Fibrosis Discovery Biology, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

8. Metabolism & Pharmacokinetics, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Cambridge, Massachusetts 02140, United States

9. Pharmaceutics, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

10. Metabolism & Pharmacokinetics, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

11. Biotransformation, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

12. Bioanalytical Chemistry, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

13. Discovery Analytical Sciences, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

14. Discovery Analytical Sciences, Small Molecule Drug Discovery, Research and Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

15. Clinical Pharmacology, Immunology, Cardiovascular and Fibrosis, Research and Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-5326, United States;

16. Nonclinical Safety Evaluation, Research & Development, Bristol Myers Squibb Company, New Brunswick, New Jersey 08903-0191, United States

17. Discovery Toxicology, Preclinical Candidate Optimization, Research and Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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