Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease

Author:

Codony Sandra1,Pont Caterina1,Griñán-Ferré Christian2ORCID,Di Pede-Mattatelli Ania3,Calvó-Tusell Carla4ORCID,Feixas Ferran4,Osuna Sílvia45ORCID,Jarné-Ferrer Júlia2,Naldi Marina6,Bartolini Manuela6ORCID,Loza María Isabel7ORCID,Brea José7,Pérez Belén8,Bartra Clara9,Sanfeliu Coral9,Juárez-Jiménez Jordi3ORCID,Morisseau Christophe10,Hammock Bruce D.10,Pallàs Mercè2ORCID,Vázquez Santiago1ORCID,Muñoz-Torrero Diego1ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona (UB), Av. Joan XXIII 27-31, E-08028 Barcelona, Spain

2. Pharmacology Section, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Neurosciences, University of Barcelona (UB), Av. Joan XXIII 27-31, E-08028 Barcelona, Spain

3. Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Theoretical and Computational Chemistry (IQTCUB), University of Barcelona (UB), Av. Joan XXIII 27-31, E-08028 Barcelona, Spain

4. CompBioLab Group, Departament de Química and Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, C/ Maria Aurèlia Capmany 69, E-17003 Girona, Spain

5. Institució Catalana de Recerca i Estudis Avançats (ICREA), E-08010 Barcelona, Spain

6. Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro, 6, I-40126 Bologna, Italy

7. BioFarma Research Group, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Av. de Barcelona s/n, E-15782 Santiago de Compostela, Spain

8. Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, E-08193 Bellaterra, Spain

9. Institute of Biomedical Research of Barcelona, CSIC and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló, 149, E-08036 Barcelona, Spain

10. Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, One Shields Avenue, Davis, California 95616, United States

Funder

National Institute of Environmental Health Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

European Regional Development Fund

Agència de Gestió d’Ajuts Universitaris i de Recerca

Xunta de Galicia

Ministerio de Educación, Cultura y Deporte

H2020 European Research Council

Agencia Estatal de Investigación, Ministerio de Ciencia, Innovación y Universidades

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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