Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer

Author:

Aicher Thomas D.1ORCID,Van Huis Chad A.1,Hurd Alexander R.1,Skalitzky Donald J.1,Taylor Clarke B.1,Beleh Omar M.1ORCID,Glick Gary2,Toogood Peter L.1,Yang Bing3,Zheng Tao3,Huo Changxin3,Gao Jie3,Qiao Chenxi3,Tian Xiaolong3,Zhang Junping3,Demock Kellie4,Hao Ling-Yang4,Lesch Charles A.4,Morgan Rodney W.4,Moisan Jacques4,Wang Yahong4,Scatina JoAnn5,Paulos Chrystal M.6,Zou Weiping7,Carter Laura L.4,Hu Xiao4

Affiliation:

1. Department of Chemistry, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States

2. Chief Scientific Officer, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States

3. Department of Chemistry, Pharmaron Beijing, Co. Ltd., Beijing 100176, P. R. China

4. Department of Biology, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States

5. Department of Preclinical Development, Lycera Corp., 620 Germantown Pike, Plymouth Meeting, Pennsylvania 19462, United States

6. Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, MSC 509, Room 203, Charleston, South Carolina 29425, United States

7. School of Medicine, Department of Surgery, University of Michigan, 2101 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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