Discovery of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition-Reference-Cited by-同舟云学术

Discovery of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition

Published:2021-04-09 Issue:8 Volume:64 Page:5082-5098
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Yuanjiang¹²,Lv Zhaodan²,Chen Feihong¹²,Wang Xing²,Gou Shaohua¹²^ORCID

Affiliation:

1. Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China

2. Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China

Funder

Ministry of Education of the People's Republic of China

Government of Jiangsu Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00131

Reference42 articles.

1. Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice

2. Protein Kinase CK2 in Human Diseases

3. Casein kinase 2α regulates glioblastoma brain tumor-initiating cell growth through the β-catenin pathway

4. Effects of the CK2 Inhibitors CX-4945 and CX-5011 on Drug-Resistant Cells

5. Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2

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