Discovery of 2-Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer

Author:

Wang Bo1ORCID,Wang Shu-Wu1,Zhou Ying1,Wang Shao-Peng1,Gao Ya1ORCID,Liu Hui-Min1,Ji Shi-Kun1,Wang Sai-Qi2,Zheng Yi-Chao1ORCID,Zhang Cheng3,Mardinoglu Adil34,Liu Hong-Min1,Chen Xiao-Bing2,Dai Xing-Jie1ORCID

Affiliation:

1. State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, XNA Platform, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China

2. Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer & Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, Zhengzhou 450008, China

3. Science for Life Laboratory, KTH-Royal Institute of Technology, SE-17121 Stockholm, Sweden

4. Faculty of Dentistry, Oral & Craniofacial Sciences, Centre for Host-Microbiome Interactions, King’s College London, London WC2R 2LS, U.K.

Funder

Henan Medical Science and Technique Foundation

Education Department of Henan Province

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

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