1,4-Disubstituted Piperazin-2-Ones as Selective Late Sodium Current Inhibitors with QT Interval Shortening Properties in Isolated Rabbit Hearts-Reference-Cited by-同舟云学术

1,4-Disubstituted Piperazin-2-Ones as Selective Late Sodium Current Inhibitors with QT Interval Shortening Properties in Isolated Rabbit Hearts

Published:2024-05-17 Issue:15 Volume:67 Page:12676-12694
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Hui¹,Jing Mengqin¹,Tian Chao¹,Li Bingxun²,Liao Weiming¹,Wang Wei¹,Li Yunzhe¹,Wang Xiaowei¹,Duan Guifang¹,Sun Qi¹^ORCID,Huang Zhuo¹³^ORCID,Wu Lin²⁴

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

2. Department of Cardiology, Peking University First Hospital, Beijing 100034, China

3. Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

4. State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China

Funder

Key Research and Development Program of Ningxia

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00677

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