The Missing Link(er): A Roadmap to Macrocyclization in Drug Discovery
Author:
Affiliation:
1. Department of Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University of Darmstadt, 64287 Darmstadt, Germany
2. Centre for Synthetic Biology, Technical University of Darmstadt, 64287 Darmstadt, Germany
Funder
Bundesministerium f?r Bildung und Forschung
Deutsche Forschungsgemeinschaft
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01163
Reference49 articles.
1. Macrocycles in Drug Discovery─Learning from the Past for the Future
2. Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors
3. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations
4. Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment
5. Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
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