Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4-Reference-Cited by-同舟云学术

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

Published:2024-08-12 Issue:16 Volume:67 Page:14493-14523
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ashton Trent D.¹²^ORCID,Calic Petar P. S.¹²^ORCID,Dans Madeline G.¹²,Ooi Zi Kang¹,Zhou Qingmiao¹,Palandri Josephine¹²,Loi Katie¹²,Jarman Kate E.¹²,Qiu Deyun³,Lehane Adele M.³^ORCID,Maity Bikash Chandra⁴,De Nirupam⁴,Giannangelo Carlo⁵^ORCID,MacRaild Christopher A.⁵^ORCID,Creek Darren J.⁵^ORCID,Mao Emma Y.⁶,Gancheva Maria R.⁶,Wilson Danny W.⁶,Chowdury Mrittika⁷⁸,de Koning-Ward Tania F.⁷⁸,Famodimu Mufuliat T.⁹^ORCID,Delves Michael J.⁹^ORCID,Pollard Harry⁹,Sutherland Colin J.⁹,Baud Delphine¹⁰,Brand Stephen¹⁰,Jackson Paul F.¹¹,Cowman Alan F.¹²,Sleebs Brad E.¹²^ORCID

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia

2. Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia

3. Research School of Biology, Australian National University, Canberra 2601, Australia

4. TCG Lifesciences, Kolkata, West Bengal 700091, India

5. Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

6. Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia

7. School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia

8. Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria 3216, Australia

9. Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.

10. MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland

11. Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC, La Jolla, California 92121, United States

Funder

National Health and Medical Research Council

Medical Research Foundation

Wellcome Trust

Australian Research Council

Australian Government

Medicines for Malaria Venture

China Scholarship Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01241

Reference54 articles.

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3. Human infections with Plasmodium knowlesi—zoonotic malaria

4. Persistent Parasitism: The Adaptive Biology of Malariae and Ovale Malaria

5. Spread of Artemisinin Resistance in Plasmodium falciparum Malaria