Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy-Reference-Cited by-同舟云学术

Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy

Published:2024-08-05 Issue:16 Volume:67 Page:14443-14465
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kim Ga-Ram¹,Kim Subin¹,Kim Yeo-Ok²,Han Xuehao²,Nagel Jessica³,Kim Jihyun¹,Song Dahin Irene⁴,Müller Christa E.³^ORCID,Yoon Myung-Ha²,Jin Mi Sun¹,Kim Yong-Chul¹^ORCID

Affiliation:

1. School of Life Sciences, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea

2. Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Republic of Korea

3. PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53113, Germany

4. Bioengineering, University of Pennsylvania, 3451 Walnut St, Philadelphia, Pennsylvania 19104, United States

Funder

Korea Research Institute of Chemical Technology

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01214

Reference51 articles.

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