Discovery of Biphenyl Derivatives to Target Hsp70-Bim Protein–Protein Interaction in Chronic Myeloid Leukemia by Scaffold Hopping Strategy-Reference-Cited by-同舟云学术

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Discovery of Biphenyl Derivatives to Target Hsp70-Bim Protein–Protein Interaction in Chronic Myeloid Leukemia by Scaffold Hopping Strategy

Published:2024-07-16 Issue:14 Volume:67 Page:12068-12084
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jiang Maojun¹,Zhang Hong¹,Song Yang²,Yin Fangkui¹,Hu Zhiyuan³,Li Xin¹^ORCID,Wang Yuying³,Wang Zheming¹,Li Yitong¹,Wang Zihan¹,Zhang Yanxin³,Wang Siyao¹,Lu Shaohua¹,Xu Guanghong¹,Song Ting¹,Wang Ziqian¹,Zhang Zhichao¹^ORCID

Affiliation:

1. Cancer Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China

2. Department of Hematology, Central Hospital of Dalian University of Technology, Dalian University of Technology, Dalian, Liaoning 116024, China

3. School of Life Science and Technology, Dalian University of Technology, Dalian, Liaoning 116024, China

Funder

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00780

Reference28 articles.

1. The Hsp70 chaperone network

2. Molecular Chaperone Hsp70 and Its Constitutively Active Form Hsc70 Play an Indispensable Role During Eye Development of Drosophila melanogaster

3. Heat Shock Proteins and Cancer

4. Hsp70 in cancer: back to the future

5. Chaperone-mediated autophagy: a unique way to enter the lysosome world

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