Structure–Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor-7 Agonist-Reference-Cited by-同舟云学术

Structure–Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor-7 Agonist

Published:2024-05-14 Issue:10 Volume:67 Page:8346-8360
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kaushik Deepender¹,Kaur Arshpreet¹,Patil Madhuri T.²,Sihag Binita¹,Piplani Sakshi³⁴,Sakala Isaac³⁴,Honda-Okubo Yoshikazu³⁴,Ramakrishnan Saravanan⁵,Petrovsky Nikolai³⁴,Salunke Deepak B.¹⁶^ORCID

Affiliation:

1. Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India

2. Mehr Chand Mahajan DAV College for Women, Sector 36A, Chandigarh 160 036, India

3. Vaxine Pty Ltd., 11 Walkley Avenue, Warradale, South Australia 5046, Australia

4. College of Medicine and Public Health, Flinders University, Bedford Park, South Australia 5042, Australia

5. Immunology Section, Indian Veterinary Research Institute, Bareilly 243122, India

6. National Interdisciplinary Centre of Vaccines, Immunotherapeutics and Antimicrobials (NICOVIA), Panjab University, Chandigarh 160 014, India

Funder

Indian Council of Medical Research

Flinders University

Panjab University

Science and Engineering Research Board

National Institute of Allergy and Infectious Diseases

Australian Government

Department of Science and Technology, Ministry of Science and Technology, India

Ministry of Education, India

Department of Science and Technology and Renewable Energy, Chandigarh Administration, Paryavaran Bhawan

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00464

Reference52 articles.

1. Toll-Like Receptors

2. Toll-like receptors: critical proteins linking innate and acquired immunity

3. TLR signaling

4. TLR ligands from the natural world

5. Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics

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1. Modulation of the Adjuvant Potential of Imidazoquinoline-Based TLR7/8 Agonists via Alum Adsorption;ACS Medicinal Chemistry Letters;2024-07-22

2. Design and Synthesis of Polyphenolic Imidazo[4,5-c]quinoline Derivatives to Modulate Toll Like Receptor-7 Agonistic Activity and Adjuvanticity;ACS Pharmacology & Translational Science;2024-06-12