Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung-Reference-Cited by-同舟云学术

Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung

Published:2024-05-01 Issue:9 Volume:67 Page:7470-7486
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Jiapeng¹^ORCID,de Melo Jorge Daniel Macedo²,Wang Weiwen¹,Sun Shuxin¹³,Frum Tristan⁴,Hang Yu-An¹,Liu Yueting¹,Zhou Xingwu³^ORCID,Xiao Jingcheng³,Wang Xinwen⁵^ORCID,Spence Jason R.⁴⁶⁷,Wobus Christiane E.²,Zhu Hao-Jie¹^ORCID

Affiliation:

1. Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States

2. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States

3. Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States

4. Department of Internal Medicine, Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States

5. Department of Pharmaceutical Sciences, Northeast Ohio Medical University College of Pharmacy, Rootstown, Ohio 44272, United States

6. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States

7. Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, Michigan 48109, United States

Funder

Horace H. Rackham School of Graduate Studies, University of Michigan

Division of Microbiology and Infectious Diseases

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00234

Reference47 articles.

1. Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2

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3. Oral antiviral treatments for COVID-19: opportunities and challenges

4. Tissue‐ and cell‐expression of druggable host proteins provide insights into repurposing drugs for COVID ‐19

5. Metabolism of Nucleosides and Nucleotides Prodrugs