Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both <i>In Vitro</i> and <i>In Vivo</i>-Reference-Cited by-同舟云学术

Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both In Vitro and In Vivo

Published:2024-04-03 Issue:8 Volume:67 Page:6658-6672
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Qi-xuan¹²³,Fan Da-meng¹²³,Zheng Zao-zao¹²³,Ran Ting⁴,Bai Ao¹²³,Xiao Rong-quan¹²³,Hu Guo-sheng¹²³,Liu Wen¹²³^ORCID

Affiliation:

1. State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang’an South Road, Xiamen, Fujian 361102, China

2. Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang’an South Road, Xiamen, Fujian 361102, China

3. Xiang An Biomedicine Laboratory, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang’an South Road, Xiamen, Fujian 361102, China

4. Bioland Laboratory (Guangzhou Regenerative Medicine and Health─Guangdong Laboratory), KaiYuan Road, Guangzhou, Guangdong 510530, China

Funder

National Key Research and Development Program of China

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00141

Reference42 articles.

1. Epigenetics and Health Disparities

2. Targeting Breast Cancer Stem Cells

3. Targeting bromodomain and extraterminal proteins in breast cancer

4. BET proteins: Biological functions and therapeutic interventions

5. A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles

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