A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current <i>In Vivo</i>-Reference-Cited by-同舟云学术

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A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current In Vivo

Published:2024-09-05 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Porro Alessandro¹,Armano Edoardo²,Brandalise Federico¹,Appiani Rebecca²,Beltrame Monica¹^ORCID,Saponaro Andrea³,Dallanoce Clelia²^ORCID,Nakajo Koichi⁴,Ryu Kaei⁴,Leone Roberta¹,Thiel Gerhard⁵^ORCID,Pallavicini Marco²^ORCID,Moroni Anna¹,Bolchi Cristiano²^ORCID

Affiliation:

1. Department of Biosciences, University of Milan, Milano 20133, Italy

2. Department of Pharmaceutical Sciences, University of Milan, Milano 20133, Italy

3. Department of Pharmacological and Biomolecular Sciences, University of Milan, Milano 20133, Italy

4. Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Kawachi District, Shimotsuke 329-0498, Japan

5. Department of Biology, TU-Darmstadt, Darmstadt 64287, Germany

Funder

Universit? degli Studi di Milano

Fondazione Telethon

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01047

Reference30 articles.

1. Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function

2. Cardiac and neuronal HCN channelopathies

3. Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels as Drug Targets for Neurological Disorders

4. Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory

5. HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain

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