A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant <i>Candida albicans</i> Strain, Computational Investigation and in Vivo Validation in a <i>Galleria mellonella</i> Fungal Infection Model-Reference-Cited by-同舟云学术

A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model

Published:2024-08-08 Issue:16 Volume:67 Page:14256-14276
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pelliccia Sveva¹^ORCID,Russomanno Pasquale²,Barone Simona¹,Mateu Baptiste¹,Alfano Antonella Ilenia¹,Miranda Martina³,Coretti Lorena¹,Lembo Francesca¹,Piccolo Marialuisa⁴,Irace Carlo⁴,Friggeri Laura⁵,Hargrove Tatiana Y.⁶,Curtis Aaron⁷,Lepesheva Galina I.⁶^ORCID,Kavanagh Kevin⁷,Buommino Elisabetta¹,Brindisi Margherita¹^ORCID

Affiliation:

1. Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy

2. Magnetic Resonance Centre (CERM), Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) and Department of Chemistry “Ugo Schiff”, University of Florence, Via L. Sacconi 6, Sesto Fiorentino 50019, Italy

3. Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany

4. BioChemLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy

5. Department of Cell and Development Biology, U4225 Medical Research Building III, 465 21st Avenue South Room 4160 MRB III Nashville, Tennessee 37232, United States

6. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

7. Department of Biology, Maynooth University, W23 F2H6 Maynooth, Co. Kildare, Ireland

Funder

H2020 Marie Sklodowska-Curie Actions

Ministero dell'Università e della Ricerca

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01109

Reference61 articles.

1. Global incidence and mortality of severe fungal disease

2. Hidden Killers: Human Fungal Infections

3. Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

4. World Health Organization. WHO fungal priority pathogens list to guide research, development and public health action; WHO, 2022; pp 1–48 .

5. Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents