Discovery of Novel Small-Molecule-Based Potential PD-L1/EGFR Dual Inhibitors with High Druggability for Glioblastoma Immunotherapy-Reference-Cited by-同舟云学术

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Discovery of Novel Small-Molecule-Based Potential PD-L1/EGFR Dual Inhibitors with High Druggability for Glioblastoma Immunotherapy

Published:2024-05-13 Issue:10 Volume:67 Page:7995-8019
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Zichao¹,Liu Ziqing¹,Wan Shanhe¹,Xu Jianwei¹,Huang Yaqi¹,He Haiqi¹,Liu Ting¹,Li Ling²,Ren Yichang¹,Zhang Jiajie¹^ORCID,Chen Jianjun¹^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

2. The Eighth Affiliated Hospital, Sun Yat sen University, Shenzhen 518033, China

Funder

Southern Medical University

National Natural Science Foundation of China

Thousand Young Talents Program of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00128

Reference70 articles.

1. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

2. Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

3. Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

4. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

5. Effects of temozolomide (TMZ) on the expression and interaction of heat shock proteins (HSPs) and DNA repair proteins in human malignant glioma cells

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