Discovery and Design of Novel Cyclic Peptides as Specific Inhibitors Targeting CCN2 and Disrupting CCN2/EGFR Interaction for Kidney Fibrosis Treatment-Reference-Cited by-同舟云学术

Discovery and Design of Novel Cyclic Peptides as Specific Inhibitors Targeting CCN2 and Disrupting CCN2/EGFR Interaction for Kidney Fibrosis Treatment

Published:2023-06-06 Issue:12 Volume:66 Page:8251-8266
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dong Jiale¹,Xiao Jing²,Li Jianyi³,Yu Huan¹,Zhao Qian¹,Tang Qinglin¹,Chen Hui¹,Liu Han¹,Wu Kejue¹,Lei Jinping¹^ORCID,Wang Rui⁴⁵^ORCID,Jiang Xianxing¹^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Outer Ring Road, Guangzhou 511400, China

2. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

3. Department of Orthopaedics and Traumatology, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan 528400, China

4. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

5. School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, 2019RU066, Lanzhou University, 199 West Donggang Rd, Lanzhou 730000, China

Funder

Guangdong Province Introduction of Innovative R&D Team

Sun Yat-sen University

National Key Research and Development Program of China

National Natural Science Foundation of China

CAMS Innovation Fund for Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00594

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