Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria

Author:

Malwal Satish R.1ORCID,Mazurek Ben1ORCID,Ko Jihee1ORCID,Xie Pujun1,Barnes Chikako2,Varvitsiotis Christine1,Zimmerman Matthew D.3,Olatunji Samir4,Lee Jaeyong5,Xie Min3,Sarathy Jansy3,Caffrey Martin4,Strynadka Natalie C. J.5ORCID,Dartois Véronique36ORCID,Dick Thomas367,Lee Bom Nae Rin8,Russell David G.8,Oldfield Eric1ORCID

Affiliation:

1. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States

2. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States

3. Center for Discovery and Innovation, 111 Ideation Way, Nutley, New Jersey 07110, United States

4. Schools of Medicine and Biochemistry & Immunology, Trinity College, Dublin D02 R590, Ireland

5. Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada

6. Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey 07110, United States

7. Department of Microbiology and Immunology, Georgetown University, Washington, District of Columbia 20007, United States

8. Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, United States

Funder

Canadian Institutes of Health Research

Science Foundation Ireland

National Institutes of Health

Mueller Health Foundation

University of Illinois Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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