Preclinical Evaluation of Novel Positron Emission Tomography (PET) Probes for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2)

Author:

Chen Zhen12ORCID,Chen Jiahui32ORCID,Mori Wakana4,Yi Yongjia1,Rong Jian32ORCID,Li Yinlong32,Leon Erick R. Calderon5,Shao Tuo2,Song Zhendong3,Yamasaki Tomoteru4,Ishii Hideki4,Zhang Yiding4,Kokufuta Tomomi4,Hu Kuan4ORCID,Xie Lin4,Josephson Lee2,Van Richard5,Shao Yihan5ORCID,Factor Stewart6,Zhang Ming-Rong4ORCID,Liang Steven H.32ORCID

Affiliation:

1. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu 210037, China

2. Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, Massachusetts 02114, United States

3. Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, Georgia 30322, United States

4. Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan

5. Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States

6. Jean and Paul Amos Parkinson’s Disease and Movement Disorder Program, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, United States

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

School of Medicine, Emory University

Publisher

American Chemical Society (ACS)

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