Discovery of the First Potent, Selective, and <i>In Vivo</i> Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of <i>TRIM37</i>-Amplified Breast Cancer-Reference-Cited by-同舟云学术

Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified Breast Cancer

Published:2023-06-06 Issue:12 Volume:66 Page:8200-8221
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sun Yin¹,Xue Yanli¹,Sun Pengkun¹,Mu Shuyi¹,Liu Hongbing²,Sun Yu¹,Wang Lin¹,Wang Jingkai¹,Wu Tianxiao¹,Yin Wenbo¹,Qin Qiaohua¹,Sun Yixiang¹,Liu Nian¹,Wang Hanxun¹^ORCID,Yang Huali¹,Zhao Dongmei¹^ORCID,Cheng Maosheng¹

Affiliation:

1. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, P.R. China

2. School of Pharmacy, Shenyang Pharmaceutical University103 Wenhua Road, Shenhe District, Shenyang 110016, P.R. China

Funder

Ministry of Education of the People's Republic of China

Program for Liaoning Innovative Talents in University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00505

Reference48 articles.

1. Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis

2. Future prospects for mitosis-targeted antitumor therapies

3. Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment

4. Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy

5. Polo-Like Kinase 4’s Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy

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