Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer-Reference-Cited by-同舟云学术

Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer

Published:2023-02-17 Issue:6 Volume:66 Page:4215-4230
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yuan Kai¹²,Shen Hongtao¹³,Zheng Mingming¹²,Xia Fei¹²,Li Qiannan¹³,Chen Weijiao¹²,Ji Minghui¹²,Yang Huanaoyu¹²,Zhuang Xujie¹²,Cai Zeyu¹²,Min Wenjian¹²,Wang Xiao¹²⁴,Xiao Yibei¹³⁴,Yang Peng¹²⁴^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China

2. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China

3. Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China

4. Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China

Funder

Ministry of Science and Technology of the People's Republic of China

State Key Laboratory of Natural Medicines

China Postdoctoral Science Foundation

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Jiangsu Funding Program for Excellent Postdoctoral Talent

Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University

“Double First-Class” University Project