1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity-Reference-Cited by-同舟云学术

1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity

Published:2023-04-11 Issue:8 Volume:66 Page:5802-5819
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Carlin Aaron F.¹²^ORCID,Beadle James R.¹^ORCID,Clark Alex E.¹,Gully Kendra L.³^ORCID,Moreira Fernando R.³,Baric Ralph S.³,Graham Rachel L.³,Valiaeva Nadejda¹,Leibel Sandra L.⁴,Bray William⁴,McMillan Rachel E.¹²^ORCID,Freshman Jonathan E.¹²,Garretson Aaron F.¹²,McVicar Rachael N.⁵,Rana Tariq⁴,Zhang Xing-Quan¹,Murphy Joyce A.¹,Schooley Robert T.¹,Hostetler Karl Y.¹^ORCID

Affiliation:

1. Department of Medicine, University of California, San Diego, La Jolla, California 92093, United States

2. Department of Pathology, University of California, San Diego, La Jolla, California 92093, United States

3. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

4. Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, United States

5. Sanford Burnham Prebys Discovery Institute, La Jolla, California 92037, United States

Funder

Center for U.S.-Mexican Studies, University of California, San Diego

National Institute of Allergy and Infectious Diseases

Burroughs Wellcome Fund

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00046

Reference35 articles.

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2. CDC. Technical Notes: Provisional Death Counts for Coronavirus Disease (COVID-19), US Department of Health and Human Services, CDC, National Center for Health Statistics, 2021; https://www.cdc.gov/nchs/nvss/vsrr/covid19/tech_notes.htm (accessed December 12, 2022).

3. Covid-19 Vaccines — Immunity, Variants, Boosters

4. SARS-CoV-2 Infection after Vaccination in Health Care Workers in California

5. The Vaccine-Hesitant Moment

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