Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment

Author:

He Siyu12,Chu Xianglin1,Wu Yujia3,Jiang Jiheng45,Fang Pengfei45ORCID,Chen Yuting1,Liu Yang1,Qiu Zhixia6,Xiao Yibei678,Li Zhiyu16ORCID,Pan Di9,Zhang Qian678,Xie Huanfang1,Xing Shuaishuai1,Feng Feng1011,Liu Wenyuan1ORCID,Guo Qinglong3ORCID,Zhao Li3,Yang Peng16,Sun Haopeng1ORCID

Affiliation:

1. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, People’s Republic of China

2. Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China

3. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, People’s Republic of China

4. School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China

5. State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

6. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China

7. Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China

8. Chongqing Innovation Institute of China Pharmaceutical University, Chongqing 4015, China

9. The Key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, Guizhou, China

10. School of Pharmacy, Nanjing Medical University, 211166 Nanjing, People’s Republic of China

11. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People’s Republic of China

Funder

?333 Project? of Jiangsu Province

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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