Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy-Reference-Cited by-同舟云学术

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Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy

Published:2024-04-15 Issue:8 Volume:67 Page:6044-6051
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kirschner Tonia¹²,Müller Matthias P.¹²^ORCID,Rauh Daniel¹²^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany

2. Drug Discovery Hub Dortmund (DDHD) am Zentrum für integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany

Funder

Bundesministerium f?r Bildung und Forschung

European Regional Development Fund

Ministerium f?r Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen

Deutsche Forschungsgemeinschaft

Mercator Research Center Ruhr

Drug Discovery Hub Dortmund, TU Dortmund University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02403

Reference46 articles.

1. RAS Proteins and Their Regulators in Human Disease

2. Mutant-Specific Targeting of Ras G12C Activity by Covalently Reacting Small Molecules

3. Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

4. Drugging the undruggable RAS: Mission Possible?

5. The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advancements in Targeted Therapeutics: Integrating Metabolic Modulation, Immune Engineering, and Biologic Formulation Technologies;ACS Medicinal Chemistry Letters;2024-08-21

2. Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display;Bioorganic & Medicinal Chemistry;2024-08

3. Innovative Therapeutic Approaches Targeting K-Ras: Analysis of Macrocyclic Compounds, Peptidomimetics, and Pyridopyrimidine Inhibitors;ACS Medicinal Chemistry Letters;2024-07-25

4. A Suite of Biochemical and Cell-Based Assays for the Characterization of KRAS Inhibitors and Degraders;2024-07-23

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