PROTACs Targeting BRM (SMARCA2) Afford Selective <i>In Vivo</i> Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models-Reference-Cited by-同舟云学术

PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models

Published:2024-01-05 Issue:2 Volume:67 Page:1262-1313
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Berlin Michael¹,Cantley Jennifer¹,Bookbinder Mark¹,Bortolon Elizabeth¹,Broccatelli Fabio²,Cadelina Greg¹,Chan Emily W.²,Chen Huifen²^ORCID,Chen Xin¹,Cheng Yunxing³,Cheung Tommy K.²,Davenport Kim¹,DiNicola Dean¹,Gordon Debbie¹,Hamman Brian D.¹,Harbin Alicia¹,Haskell Roy¹,He Mingtao³,Hole Alison J.⁴,Januario Thomas²,Kerry Philip S.⁴,Koenig Stefan G.²^ORCID,Li Limei³,Merchant Mark²,Pérez-Dorado Inmaculada⁴,Pizzano Jennifer¹,Quinn Connor¹,Rose Christopher M.²^ORCID,Rousseau Emma¹,Soto Leofal¹,Staben Leanna R.²,Sun Hongming³,Tian Qingping²,Wang Jing¹,Wang Weifeng³,Ye Crystal S.²,Ye Xiaofen²,Zhang Penghong³,Zhou Yuhui²,Yauch Robert²,Dragovich Peter S.²^ORCID

Affiliation:

1. Arvinas LLC, 5 Science Park, New Haven, Connecticut 06511, United States

2. Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

3. Pharmaron Beijing, Co. Ltd., 6 Tai He Road, BDA, Beijing 100176, P. R. China

4. Evotec (U.K.) Ltd., 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01781

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